Comparative Study on Clinical Characteristics of HBV/HCV Co-infection Patients with HBeAg-positive and HBeAg-negative

[Objective] The purpose of this study was to investigate the clinical characteristics in HBV/HCV co-infected patients with HBeAg-positive and HBeAg-negative.[Methods] A total of 186 HBV/HCV co-infected patients were retrospectively analyzed.The epidemiological,biochemical,and virological characteristics were collected.Univariate analysis was performed with the SPSS 16.0.[Results] Of the 186 cases,140 were HBeAg-negative and 46 were HBeAg-positive.Compared with HBeAg-positive patients,HBeAg-negative patients had elder age,higher TBil levels,higher virus levels and more blood transfusioner(P0.05).However,ALT levels of HBeAg positive patients were higher than that of HBeAg negative patients(P = 0.031).The rate of HBV DNA positive in HBeAg negative patients was higher than that in HBeAg positive patients(P = 0.000).There was no difference of HCV RNA levels between HBeAg-positive patients and HBeAg-negative patients(P = 0.169).Other clinical characteristics was no difference(P 0.05).[Conclusions] The clinical characteristics of HBV/HCV co-infection patients with HBeAg-positive and HBeAg-negative were different;these differences were also not same as that of HBV infected patients.HBeAg reflect the HBV DNA levels of HBV/HCV co-infected patients.HBeAg states has nothing to do with the level of HCV RNA.