2012•Jiangsu Medical JournalRequires access
Value of RUNX3 gene promoter methylation in diagnosis of non-small cellular lung cancer
Mingfeng Zheng
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Abstract
Objective To investigate the value of RUNX3 gene promoter methylation in diagnosis of non-small cellular lung cancer(NSCLC). Methods The methylation of RUNX3 gene promoter was analyzed in 58 NSCLC tissues and tumor-adjacent normal lung tissues by methylation-specific-PCR. The correlation between methylation of RUNX3 gene promoter and clinicopathological characteristics was statistically analyzed as well.Results Twenty-six(44.8%) tissues with methylation of RUNX3 gene promoter in 58 NSCLC tissues was detected,which was significantly higher than 10(17.2%) tumor-adjacent normal lung tissues(P0.01).The methylation of RUNX3 gene promoter was closely relatedtoclinical stage,lymph node metastasis and differentiation degree of NSCLC(P0.05). Conclusion The high methylation rate of RUNX3 gene promoter exists in NSCLC tissues.The methylation of RUNX3 gene promoter is closely related to clinical stage,lymph node metastasis and differentiation degree and has an important significance in the diagnosis and evaluation of prognosis of NSCLC.