ScholarLens Back to search
2013•Journal of Clinical HematologyRequires access

Significance and expression of CD117 and CD34 in acute leukemia cells

Hongyu Zhang

Open publisher page 0 citations

Abstract

Objective:To explore the significance and expression of CD34 and CD117 on different types of acute leukemia cells. Method:The expression of CD34 and CD117 in acute leukemia cells from 34 patients(including 9 ALL and 25 AML) were detected by flow cytometry. Result:The positive rate of CD117 was significantly lower in ALL patients than that in AML patients(0 vs 76.0%,P=0.000).There was no significant difference in the positive rate of CD34 between ALL and AML patients(77.8% vs 60.0%,P=0.815).The positive rate of CD34 in non-M3 subtype was significantly higher than that in AML-M3 subtype(73.7% vs 16.7%,P=0.007). Conclusion:CD117 may be used as an immunologic marker for AML.CD34 may be used to distinguish the diagnosis between AML-M3 subtype and non-M3 subtype.

About this research paper

What this paper is about

Objective:To explore the significance and expression of CD34 and CD117 on different types of acute leukemia cells. Method:The expression of CD34 and CD117 in acute leukemia cells from 34 patients(including 9 ALL and 25 AML) were detected by flow cytometry. Result:The positive rate of CD117 was significantly lower in ALL patients than that in AML patients(0 vs 76.0%,P=0.000).There was no significant difference in the positive rate of CD34 between ALL and AML patients(77.8% vs 60.0%,P=0.815).The positive rate of CD34 in non-M3 subtype was significantly higher than that in AML-M3 subtype(73.7% vs 16.7%,P=0.007). Conclusion:CD117 may be used as an immunologic marker for AML.CD34 may be used to distinguish the diagnosis between AML-M3 subtype and non-M3 subtype.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To explore the significance and expression of CD34 and CD117 on different types of acute leukemia cells. Method:The expression of CD34 and CD117 in acute leukemia cells from 34 patients(including 9 ALL and 25 AML) were detected by flow cytometry. Result:The positive rate of CD117 was significantly lower in ALL patients than that in AML patients(0 vs 76.0%,P=0.000).There was no significant difference in the positive rate of CD34 between ALL and AML patients(77.8% vs 60.0%,P=0.815).The positive rate of CD34 in non-M3 subtype was significantly higher than that in AML-M3 subtype(73.7% vs 16.7%,P=0.007). Conclusion:CD117 may be used as an immunologic marker for AML.CD34 may be used to distinguish the diagnosis between AML-M3 subtype and non-M3 subtype.

Key concepts: CD117, CD34, Flow cytometry, Acute leukemia, Leukemia, Medicine, Clinical significance, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Significance and expression of CD117 and CD34 in acute leukemia cells — Research Paper | ScholarLens