2000•The Orthopedic Journal of ChinaRequires access
The Changes of Bone Density and Biomechanics in Female Rat following Nerve Injury and Immobilization
Hong Zhang
Open publisher page 0 citations
Abstract
Objective: To investigate the effects of nerve injury and immobilization on bone density and biomechanics.Methods:40 female SD rats were randomly divided into groups.The BMD of femur、tibia were measured before operation and 12 weeks after operation.Three point bending test was carried out to determine the maximum load of the femur and the tibia after the rats were killed.Results:The BMD changes of the femur and the tibia are statistically significant between the experimental and the control group( P 0.01).The decreases of the maximum load the femur and the tibia are statistically significant between the experimental and the control group( P 0.01).The BMD changes of the femur and the tibia were significantly correlated with the maximum load (r=0.89,0.01 P 0.05;r=0.99, P 0.01).Conclusion:The effect on BMD of the fumur and the tibia by nerve injury and immobilization was significntly different Nerve injury and immobilization induce the decrease of biologic mechanisms.