Influence of rocuronium on bispectral index during different effect-site concentration of propofol

Objective To investigate whether rocuronium could affect bispcetral index during different effect-site concentration of propofol.Methods Sixty ASA Ⅰ or Ⅱ patients undergoing elective surgery were enrollded in the study,based on Ce of propofol,the patients randomly divided into four groups with 15 cases in each group (group R2 and R3) and (group C2 and C3).When the Ce of propofol reached 4.0 μg/ml and OAA/S score was below one,a laryngeal mask airway was inserted,Ce was then maintained at 2.0 μg/ml or 3.0 μg/ml for 20 min. Rocuronium of 0.6 mg/kg about 2ED95 was given in groups R2 and R3,normal saline in the volume of 5 ml was given in the other two groups. BIS、HR and MAP values were recorded before induction of propofol immediately(T1),at the time of injection rocuronium or normal saline(T2),when TOF reached 0(T3) and at the first TOF twitch of muscle recovered to 5% (T4). Results The BIS at T3and T4were significantly lower than that at T2in group R2,but not in group R3,C2 or C3. Compared with the same Ce,there was no significant difference between group R2,C2 and group R3,C3. Conclusion Rocuronium could reduce the BIS scores in moderately sedated patients but not in deeply sedated patients.