LZBZY's regulatory effect on the growth of H_(22) tumor and the expression of VEGF in transplanted H_(22) tumor of mice

Aim To observe the regulatory effect of LZBZY on the growth of H22 tumor and the expression of vascular endothelial growth factor(VEGF) in transplanted H22 tumor of mice,and explore whether the inhibition of tumor is related to the inhibition of vascular growth.Methods The mice were vaccinated with H22 cells suspension(1×107/ml) 0.2 ml each one.The observation was made on the weight of the transplanted tumor of the mice,then the inhibitory rate was calculated.The expression of VEGF was determined by the immunohistochemical method.Results The LZBZY group had significant effect on inhibiting the tumor growth(P0.05,P0.01),when compared with the model group,the pathological detective results showed that the positive rate of expression of VEGF was 100% in each group with the degree difference.Moreover,the expression of VEGF was decreased obviously in LZBZY group(P0.05,P0.01).Conclusion The LZBZY can inhibit the growth of the transplanted H22 tumor of mice and decrease the expression of the VEGF.