The expression and activity of protein kinase AIin oral squamous cell carcinoma

PURPOSE:To detect the expression and distribution of protein kinase AⅠ(PKAⅠ)in oral squamous cell carcinoma as well as its clinicalpathological significance.METHODS:The expression of PKAⅠwas investigated in 40 oral squamous cell carcinomas and 15 normal tissues by immunohistochemistry.The activity of PKAI was detected in 20 human oral squamous cell carcinomas and adjacent normal tissues with Western blot.The data was analysed with SPSS 11.5 for Student's t test,Chi-between different square test and linear correlation analysis.RESULTS:The expression of PKAⅠwas significantly higher in oral squamous cell carcinomas than in normal tissues(P0.05).There were no differences degrees of histodifferentiation and clinical phases(P0.05).The activity of PKAⅠwas significantly higher in oral squamous cell carcinomas than in normal tissues(P0.01),there were obvious dependability of the expression and activity of PKAⅠ(P0.01).CONCLUSIONS:Protein kinase AⅠhighly expressed in oral squamous cell carcinomas,but was not related to the degree of histodifferentiation and the clinical phases.Oral squamous cell carcinoma correlated with the expression and activity of PKAⅠand the activation of PKAⅠwas one of the factors for proliferation of oral squamous cell carcinoma.Supported by Research Fund of Ministry of Public Health(96-1-219).