Sex differences in treatment and in-hospital mortality after acute myocardial infarction

Objective:To analyze gender differences of in-hospital mortality and related risk factors in patients with AMI.Methods:A retrospective of study was carried out in 1 034 patients with AMI(male,718;female,316).Results:The female patients with AMI were older than male patients [(70.1 ± 8.8) years vs(62.3 ± 12.1) years,P0.001].They had higher prevalence of hypertension,diabetes,angina and Killips’ grade≥III rank(20.4% vs 11.3%,P0.001).In-hospital mortality rates of female patients with AMI and ST segment elevation myocardial infarction(STEMI) were higher than male patients(15.5% vs 5.7%,P0.001;16.1% vs 5.7%,P0.001).And they were less likely to receive β-blocker and primary PCI than male patients(64.6% vs 73.4%,P0.05;16.5% vs 32.0%,P0.001).Multivariable Logistic regression analysis of all AMI patients showed that female,age≥70 years,the history of angina and smoking,Killips’ grade≥III rank were independent risk factors.Emergency PCI was independent protective factor(adjusted OR=0.323;95%CI,0.123~0.852).Conclusion:Female patients’cardiac functions are worse.They are less likely to receive β-blocker and interventional therapies.In-hospital mortality rates of female patients with AMI and STEMI are both higher than male patients.