PROTECTIVE EFFECTS OF NICORANDIL ON PATIENTS WITH UNSTABLE ANGINA PECTORIS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Objective To observe the myocardial protective effect of oral Nicorandil on patients with unstable angina pectoris(UAP) undergoing percutaneous coronary intervention(PCI) therapy.Methods Sixty patients with UAP needed PCI were equally randomized to Nicorandil group and control group.The patients in control group were given a conventional therapy,those in Nicorandil group were added Nicorandil,5 mg,three times a day,48 hours prior to PCI,in addition to routine therapy.The medication was continued for eight weeks after PCI.Serum concentrations of creatine kinase-MB(CK-MB) and cardiac troponin I(cTnI) were measured in both of the groups before and 6,12,and 24 h after PCI.The electrocardiogram(ECG) and left ventricular ejection fraction(LVEF) were observed eight weeks after the procedure.Results The serum levels of CK-MB and cTnI were significantly lower in the Nicorandil group than that in the control group 24 h after PCI(t=2.040,2.241;P0.05).Post-PCI serum CK-MB and cTnI elevated were noted in five patients(16.7%) in Nicorandil group and 13(43.3%) in the control group,the difference being significant between the two groups(P=0.047).Follow-up ECG and echocardiography conducted eight weeks after PCI revealed that the ECG and LEVF improved better in Nicorandil group than the control(u=2.475,t=2.061;P0.05).Conclusion Oral administration of Nicorandil has a definite myocardial protection in patients with UAP undergoing PCI.