Comparison of Distribution in Tissues between Rectal and Injecting Administration of Fluorouracil

Objective To study the distribution in tissues between rectal and systemic injection of 5-fluorouracil in human beings.Methods 16 patients with rectal cancer needing operation were randomly divided into two groups.One group was treated with 400 mg 5-fluorouracil suppository by rectum 1h before operating,the other group were treated with 400 mg 5-fluorouracil by infusion 1h before operating.During operation kept the normal tissues around of cancerous areas and rectal cancer tissues.The 5-fluorouracil levels in,rectal cancer tissues and muscle around,draining lymph node and peripheral blood were measured by HPCL.Results After treated with 5-fluorouracil suppository,the 5-fluorouracil levels in cancer tissues,in muscles up the rectal wall,down rectal walls,in draining lymph node and in peripheral blood was 21.68,13.57,15.41,2.14,and 0.068,respectively.The 5-fluorouracil levels from the same areas as above after drop infusion of 5-Fu were 4.57,0.074,0.064,1.69and 0.025 μg·g-1.Conclusion The 5-Fu levels in cancer and peripheral tissues could be significantly elevated by using than those by infusion 5-Fu.The 5-Fu suppository can more efficaciously prevent the cancer cells from implanting and transferring during the operations.Meanwhile,it can efficaciously reduce the side-effects caused by chemotherapy.