The Clinical Analysis of Hyperphosphatemia in Maintenance Hemodialysis Patients

Objective: To compare the clinical feature and laboratory examination indexes of different serum phosphorus levels in uremia patients treated with maintenance hemodialysis and explore its clinical significance.Methods:According to the serum phosphorus levels,58 maintenance hemodialysis patients from department of nephrology,Xinghua Hospital Affiliated to Shanghai Jiaotong Universi-ty School of Medicine were divided into two groups,including 28 cases of case group(SP1.6mmol/L) and 30 cases of control group(SP≤1.6mmol/L).The protopathy,age,gender,duration of hemodialysis,blood calcium,bicarbonate,hemoglobin,hematocrit,blood alkaline phosphatase,renal function,level of plasma albumin and incidence of itchy skin,low back pain and left ventricular hypertrophy between the two groups were all compared and analyzed.Results: Two groups of patients in basic information including protopathy,age(43.2±9.8 years vs.40.5±12.2 years),sex ratio(16/12 vs.17/13),duration of hemodialysis(32.56±6.71 month vs.35.43±5.82 month) were no significant difference(P0.05).There were significant difference between case group and control group on the hemoglobin(83.22±6.71g/L vs.103.36±5.84g/L),hematocrit(24.83±1.92% vs.30.76±1.52%),blood calcium(1.71±0.16mmol/L vs.2.23±0.21 mmol/L),bicarbonate(14.2±3.1mmol/L vs.20.6±4.9 mmol/L),blood alkaline phosphatase(124.26±16.33U/L vs.61.47±14.91 U/L),incidence of itchy skin(22/28 vs.7/30),low back pain(19/28 vs.6/30),and left ventricular hypertrophy(20/28 vs.12/30)(P0.05),but the creatinine(956±142mmol/L vs.923±156 mmol/L),urea nitrogen(23.1±6.3mmol/L vs.24.8±8.9 mmol/L),plasma albumin(30.5±3.8g/L vs.31.2±2.9g/L) were not statistically significant(P0.05).Conclusions: Compared with patients with normal serum phosphorus,maintenance hemodialysis patients with hyperphosphatemia has higher blood alkaline phosphatase,incidence of itchy skin,low back pain and left ventricular hypertrophy,and lower blood calcium,bicarbonate,hemoglobin,hematocrit.