Effect of penehyclidine on tidal volume and pulmonary compliance in elder patients during general anesthesia

Objective To investigate the effect of penehyclidine on tidal volume(VT) and lung compliance(CL) in elder patients during general anesthesia.Methods Forty ASA Ⅰor Ⅱ patients scheduled for selective operation under general anesthesia were equally divided into 2 groups of adult group(30-55 years old) and old group(65-85 years old).Anesthesia was induced with midazolam 0.03 mg/kg,propofol 2 mg/kg,fentanyl 3 μg/kg,vecuronium 0.1 mg/kg.Anesthesia was maintained with propofol and vecuronium continuous intravenous infusion.Pressure controlled ventilation was performed after tracheal intubation.PETCO2 was maintained at normal range.Penehyclidine 0.02 mg/kg was administered IV.in two groups at 20 min after tracheal intubation.HR,MAP,SpO2,PETCO2,VT and CL were monitored continuously.Arterial blood gas analysis was performed as well.Results There were no significant differences in HR and MAP between the two groups.Compared with those in adult group,VT and CL were significantly decreased before penehyclidine injection(P0.05) and increased then after in old group.Conclusion During general anesthesia elder patients,intravenous injection of penehyclidine can dilate the bronchus and increase CL without influence on hemodynamics.