2005•Chinese Journal of Laboratory DiagnosisRequires access
The regulation of protein kinase C in eosinophil apoptosis
LI Qiu-sh
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Abstract
Objective To study The regulation of protein kinase C in eosinophil apoptosis.Methods With in situ hybridization and immunohistochemistry methods,in 26 nasal polys specialized by eosinophil infiltration and proliferation,and PKC and anti-apoptotic gene bcl-2mRNA and associated protein were messured;in cell-cultured way,with PKC inhibitor—Iso-H7 to measure Eosinophil apoptotic index.Results The expression of PKC and bcl-2 mRNA as well as associated protein in eosinophils showed remarkably positive relation respectively(r_1=0.0875,r_2=0.0823,P0.01).The inhibitor of PKC could significantly promote eosinophil apoptosis.Conclusion PKC could inhibit eosinophil apoptosis,and it will provide new methods in treating diseases of eosinophil infiltration and proliferation in fulture.