Relationship between loss of 53BP1 expression and clinical pathology in prostate adenocarcinoma

Purpose To study the expression of tumor protein p53 binding protein 1(53BP1) in prostate adenocarcinoma,adjacent benign prostate tissue,high grade prostatic intraepithelial neoplasia(HGPIN),benign prostatic hyperplasia(BPH) and its clinicopathologic significance.Methods Immunohistochemical study for 53BP1 was performed on paraffin sections of 50 cases of prostate adenocarcinoma and adjacent benign prostate tissue,20 cases of high grade prostatic intraepithelial neoplasia,20 cases of benign prostatic hyperplasia,and its value was discussed for tumorigenesis of prostate adenocarcinoma.Results Immounohistochemical study showed the epithelial cells of benign prostatic hyperplasia,high grade prostatic intraepithelial neoplasia,adjacent benign prostate tissue,and prostate adenocarcinoma cells were positive for 53BP1 in the nucleus,which was decreased gradually.The expression in the epithelial cells of benign prostatic hyperplasia,high grade prostatic intraepithelial neoplasia and adjacent benign prostate tissue were significantly higher than that in prostate adenocarcinoma cells(P=0.015).53BP1 expression in adjacent benign prostatic epithelial cells and high grade prostatic intraepithelial neoplasia was significantly lower than that in benign prostatic hyperplasia epithelial cells(P=0.035).However,there was no statistical differences between adjacent benign prostate epithelial cells and high grade prostatic intraepithelial neoplasia(P=0.658).53BP1 expression was much lower in ≤68-year-old group than in 68-year-old group(P=0.001).Conclusions As a tumor suppressor gene,loss of 53BP1 expression may play a role in the initiation of human prostate adenocarcinoma.It may become an indicator of early-stage prostate adenocarcinoma.