Measurement of optic disc nerve fiber layer surrounding area and macular thickness of retinal for diagnosis value of glaucoma by OCT

【Objective】To compare optic disc nerve fiber layer surrounding area(RNFL) thickness and macular retinal thickness(MRT) by OCT for diagnosis of glaucoma.【Methods】48 patients(71 eyes) with glaucoma were included in the study,and 40 healthy(63 eyes) were also included as healthy control group.All candidates examined NFL by OCT.We used ROC curves and area under the curve(AUC) to compare the diagnosis value.【Results】The average RNFL(t =12.950,P =0.000) and macular thickness(t =8.917,P =0.000) in patients with glaucoma were thinner than that of the control group;and RNFL thickness in glaucoma nega-tive correlated with the severity of glaucoma rs was 0.361(t =4.516,P =0.024),so as to macular thickness,rs was 0.337(t =4.249,P =0.035).RNFL thickness has higher diagnosis effect than macular thickness by AUC comparison,and the best diagnosis effect is 6 o'clock of RNFL thickness(95% CI 0.664~0.865).Under the appropriate diagnostic cutoff value,the diagnostic specificity,sensitivity,diagnostic accuracy for 6 o'clock RN-FL and macular was 85.6%,91.2%,87.1% and 80.2%,88.4%,84.6%,respectively.【Conclusion】The RNFL thickness of the optic disc and macular thickness also have a good diagnosis effect for glaucoma,but the thickness of lower area of RNFL has the best diagnosis value.