Analysis of the karyotypes and natural stature in 125 patients with Turner syndrome

Objective To analyze the karyotypes and natural stature in patients with Turner syndrome, and to provide a method of early clinical detection. Methods The karyotypes and natural stature of 125 patients were analyzed during the period of 1982～2000 by the technique of G band; and C band, N band, and the high resolution were used when necessary. Results The karyotypes were mainly 45, XO (33.6%); 45, XO/46, X, i (Xq) (16%); 45, XO/46, XX (10.4%); 46, X, i (Xq) (8.8%); 45, XO/46, XY (8.8%). The mean adult height was (137.8±9.9) cm, which was shorter than the normal standard. The patients with the karyotypes of 45, XO were shorter than those with the karyotypes of non 45, XO, and a significant difference was observed when the patients' age was 14 years. Conclusion The loss in height most likely happens before the age of 14 years, which implies that earlier diagnosis and treatment should be taken.