Clinicopathologic study on c-erbB-2 oncoprotein expression of breast cancer

Objective To study c erbB 2 oncoprotein expression of breast cancer and its biological significance. Methods c erbB 2 protein expression was detected in 554 cases of breast cancer and 100 cases of benign breast tissues adjacent to breast cancer by using immunohistochemical SP method. Results Five cases with benign breast tissues and 334 cases with breast cancer expressed c erbB 2 oncoprotein. Staining was more evident at the infiltrating margins than that at the center of the cancer. c erbB 2 expression was associated with the degree of epithelial hyperplasia, histologic typing and grading (P0.01), but it was not correlated to age, lymphnode involvement, tumor size and TNM stages. Conclusions Detection of c erbB 2 expression may be helpful to differential diagnosis of breast cancer and judge its differentiation.