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2006•Heilongjiang Medical JournalRequires access

Study of Association Between Serum Interleukin-18,TNF-α and Insulin Resistance in type 2 Diabetes Mellitus

Min Chen

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Abstract

Objective To assess the assouation of serum Interliukin-18,TNF-α and insulin resistance in type 2 diabetes mellitus.Methods 62 T2DM patients and 40 non-diabetic controls were selected levels of Interliukin-18,TNF-α meal measured.Fasting blood glucose and fasting insulin,blood lvpid,BMI and WHR were measured.Homa-IR were calculated.Results The levels of serum Interliukin-18,TNF-α and Homa-IR in T2DM group were significantly higher than those in control group.IL-18 and TNF-α level of serum was positively corrdated with Homa-IR.IL-18 level of serum was positively associated with BMI and WHR.Conclusion IL-18,TNF-α independent risk foctors for IR may be involved in T2DM development,and it could reflect the degree of insulin resistance indirectly.

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Objective To assess the assouation of serum Interliukin-18,TNF-α and insulin resistance in type 2 diabetes mellitus.Methods 62 T2DM patients and 40 non-diabetic controls were selected levels of Interliukin-18,TNF-α meal measured.Fasting blood glucose and fasting insulin,blood lvpid,BMI and WHR were measured.Homa-IR were calculated.Results The levels of serum Interliukin-18,TNF-α and Homa-IR in T2DM group were significantly higher than those in control group.IL-18 and TNF-α level of serum was positively corrdated with Homa-IR.IL-18 level of serum was positively associated with BMI and WHR.Conclusion IL-18,TNF-α independent risk foctors for IR may be involved in T2DM development,and it could reflect the degree of insulin resistance indirectly.

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Available abstract

Objective To assess the assouation of serum Interliukin-18,TNF-α and insulin resistance in type 2 diabetes mellitus.Methods 62 T2DM patients and 40 non-diabetic controls were selected levels of Interliukin-18,TNF-α meal measured.Fasting blood glucose and fasting insulin,blood lvpid,BMI and WHR were measured.Homa-IR were calculated.Results The levels of serum Interliukin-18,TNF-α and Homa-IR in T2DM group were significantly higher than those in control group.IL-18 and TNF-α level of serum was positively corrdated with Homa-IR.IL-18 level of serum was positively associated with BMI and WHR.Conclusion IL-18,TNF-α independent risk foctors for IR may be involved in T2DM development,and it could reflect the degree of insulin resistance indirectly.

Key concepts: Medicine, Insulin resistance, Internal medicine, Endocrinology, Type 2 Diabetes Mellitus, Diabetes mellitus, Insulin, Tumor necrosis factor alpha

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