Dynamic observation of pathological changes of liver in biliary obstruction rats

Objective To establish the animal models of SD rat biliary obstruction,and pathological changes of liver and liver function indicators on the animal model of dynamic observation. Methods The pure line of 35 SD rats,were randomly divided into experimental group and control group,the experimental group underwent common bile duct ligation,then close the abdominal. The control group after open abdomen from the common bile duct and abdominal closure. Dynamic observation of bile duct ligation after first days,3 days,7 days,14 days,21 days of liver function,pathological changes of hepatic tissues. Results In rats with obstructive jaundice in 14 days with the prolongation of time,serum bilirubin increased gradually,the small intrahepatic bile duct proliferation increased gradually,with little fibrous connective tissue hyperplasia. After 14 days of serum bilirubin decreased gradually,small bile duct hyperplasia reduce,also has not seen the hyperplasia of fibrous connective tissue. Conclusion Jaundice Rat Liver and liver function obstruction in 14 days changes similar to humans,but in 14 days after the surgery the rats appeared recovery,unlike human obstructive jaundice disease process.