Research on the relationship between Nectin-4 and cancer

Nectin-4 is a member of the Nectin family that belongs to the immunoglobulin superfamily(IgSF),which is a new component of adhesion molecules.The abnormal expression of Nectins would lead cells to lose their stability and contribute to the occurrence and development of malignant tumors.Nectin-4 is indeed not detected in normal adult tissues,but highly expressed in tumor cell lines.The relationship of Nectin-4 with tumors is described,and the fact that Nectin-4 would provide new scientific evidence for diagnosis and treatment of human tumor is presented.