Clinical observation on treatment of advanced non-small cell lung cancer with the regimen containing main- ly navelbine

Objective To evaluate the efficacy and toxicity of NIP(NVB + IFO + DDP)regimen and NP (DDP+ NVB)regimen in treatment of non-small cell lung cancer(NSCLC). Methods Forty-eight cases of advanced NSCLC were randomly divided into NIP regimen group and NP regimen group. Results The results showed that the response rates of NIP group and NP group were 54.1% and 45.9% respectively, with no statistically significant difference between them( P 0.05) .The dose-limiting toxicity was neutropenia which was seen in all treated cases and 70.8% and 62.5% were grade III and grade IV inhibition in NIP group and NP group respectively. Gastric irritation was tolerable. Conclusion Both of these two regimens are effective and tolerable in the treatment of advanced NSCLC.The regimen of NVB,DDP plus IFO is better than NVB plus DDP. Although the former causes more severe toxic reaction, it can be tolerable.