Bupropion sustain-release in treatment of depression with anxiety

Objective To evaluate the efficacy and safety of bupropion hydrochloride sustain-release tablet(bupropion SR)in the treatment of depression with anxiety.Methods One hundrend and fourty-four inpatients and outpatients with depression were randomly assigned to receive Bupropion SR(n=72)or Fluoxetine(n=72)for up to 42 days in this randomized,paralled-group study.Fourty-four patients whose Hamilton Anxiety Scale(HAMA)≥14 received additional analysis.Therapeutic efficacy was assessed with the HAMA and Hamilton Rating Scale for Depression(HAMD).Safety profile was assessed with the Treatment Emergent Symptom Scale(TESS).Results(1)The therapeutic efficiency in treating depression with anxiety was not statistically different between bupropion SR and fluoxetine(P0.05),however,the onset time is earlier in bupropion SR treated group,especially in the female group.(2)Safety:The side effects was not statistically different between gastrointenstinal tract reaction,insomnia and perspiration et al.Conclusions The therapeutic effect and side effect on depression with anxiety is not different between bupropion SR and fluoxetine.The onset time in bupropion SR appears earlier than fluoxetine.