Synthesis and antifungal activities of 1-(1H-1,2,4-triazol-1-yl)-2-(3,3-dimethyl)-3-[(4-substituted)-piperazin-1-yl]-2-propanols

Aim To study the antifungal activities of the triazole derivatives with the side chain containing tert-butyl and to compare their antifungal activities with that of fluconazole and itraconazole.Methods According to the structure of fluconazole,ten target compounds were designed and synthesized.All of them were confirmed by 1H-NMR and IR spectra,all and partly,respectively.The MIC80 of all the target compounds were determined by the method recommended by the national committee for clinical laboratory standards(NCCLS) using the RPMI-1640 test medium.Results All the target compounds were firstly reported.The results of the preliminary antifungal test show that all the target compounds exhibit potent antifungal activities to a certain extent.Conclusion Stereochemistry has important influence on the antifungal activities of the target compounds.