Research Progress on Aminoacyl-tRNA Synthetases

Aminoacyl-tRNA synthetases catalyze the attachment of specific amino acids to their cognate tRNAs,thereby ensuring the faithful translation of genetic code.In addition to their enzymatic function,these ancient and conserved enzymes have been discovered to have many additional functions in mammalian cells.As a result,several application aspects have been found.Aminoacyl-tRNA synthetases have attracted interest as essential and novel targets involved in bacterial protein synthesis,and they are now being pursued as targets for new antibiotic drugs.Engineered aminoacyl-tRNA synthetases are uesed for site-specifically incorporation of non-natural amino acids.The results with animals suggest that therapeutic applications for many human diseases such as tumor are possible with the cognate tRNA synthetases.