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2006•Chinese Journal of Birth Health & HeredityRequires access

Analysis of prenatal screening 4121 cases in mid-pregnant women

Rong Qiang

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Abstract

Objective: To research the effect of the maternal serum markers of Alpha-fetoprotein(AFP),human chorionic gonadotrophin(free beta-hCG) in the congenital fetal abnormality screening such as Down′s Syndrome in mid-pregnancy women.Methods: Serum screening of AFP and beta-hCG were offered to the 14-20 weeks pregnant women and combined with the maternal age,week and weight to detect the amniotic fluid cell chromosomes and B-ultrasonography in the high risk women by measuring the high risk rate with special software.Each case was followed till the fetus Born.Results:There were 3 case of DS and 6 cases of other fetal abnormality between 4121 pregnant women.Conclusion: The combination of the serum biochemistry results of AFP and free beta-hCG can be useful markers to detect Down′s syndrome and can decrease 2.81‰ of congenital fetal malformation.

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What this paper is about

Objective: To research the effect of the maternal serum markers of Alpha-fetoprotein(AFP),human chorionic gonadotrophin(free beta-hCG) in the congenital fetal abnormality screening such as Down′s Syndrome in mid-pregnancy women.Methods: Serum screening of AFP and beta-hCG were offered to the 14-20 weeks pregnant women and combined with the maternal age,week and weight to detect the amniotic fluid cell chromosomes and B-ultrasonography in the high risk women by measuring the high risk rate with special software.Each case was followed till the fetus Born.Results:There were 3 case of DS and 6 cases of other fetal abnormality between 4121 pregnant women.Conclusion: The combination of the serum biochemistry results of AFP and free beta-hCG can be useful markers to detect Down′s syndrome and can decrease 2.81‰ of congenital fetal malformation.

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Available abstract

Objective: To research the effect of the maternal serum markers of Alpha-fetoprotein(AFP),human chorionic gonadotrophin(free beta-hCG) in the congenital fetal abnormality screening such as Down′s Syndrome in mid-pregnancy women.Methods: Serum screening of AFP and beta-hCG were offered to the 14-20 weeks pregnant women and combined with the maternal age,week and weight to detect the amniotic fluid cell chromosomes and B-ultrasonography in the high risk women by measuring the high risk rate with special software.Each case was followed till the fetus Born.Results:There were 3 case of DS and 6 cases of other fetal abnormality between 4121 pregnant women.Conclusion: The combination of the serum biochemistry results of AFP and free beta-hCG can be useful markers to detect Down′s syndrome and can decrease 2.81‰ of congenital fetal malformation.

Key concepts: Fetus, Medicine, Prenatal screening, Obstetrics, Pregnancy, Abnormality, Gynecology, Alpha-fetoprotein

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