Transsphenoidal hypophysectomy and its effects on endocrinological status and serum chemistry parameters in dogs with Cushing’s disease

Cushing’s disease is a common endocrinopathy in dogs that is caused by an adrenocorticotropic hormone(ACTH)secreting corticotroph adenoma.Most dogs with Cushing’s disease have been treated by mitotane or trilostane in small animal clinical medicine[1,2,15-17].In humans,however,the first choice f treatment for Cushing’s disease is transsphenoidal hypophysectomy(TSS)[3,4,6].In human clinical medicine,it has been suggested that excessive suppression of cortisol production using these drugs for the patients with Cushing’s disease might delete the negative feedback effect of cortisol to the hypotahalamus and corticotrophs,and result in promoting the growth of ACTH secreting corticotroph adenoma,