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Immunohistochemical study of TGF-β_1, TGF-β_2 and TGF-β_3 protein expressions in human tooth germs

Junnan Shi

Abstract

AIM: Study of the effect of TGF-β 1, TGF-β 2 and TGF-β 3 in the human tooth development. METHODS: SP IHC was used to detect the localization of TGF-β 1, TGF-β 2 and TGF-β 3 protein on human tooth germs sections(16th to 28th gwk). RESULTS: TGF-β 1 and TGF-β 3 mainly expressed in ameloblasts and odontoblasts. TGF-β 2 mainly expressed in inner enamel cells and ameloblasts. TGF-β 1、TGF-β 2 and TGF-β 3 demonstrated positive expression in the enamel knot. CONCLUSION: TGF-β 1、TGF-β 2 and TGF-β 3 are important regulators in the human tooth development. They are involved in tooth germ cytodifferention, promote the secretion of the dentin matrixes, and regulate the tooth morphogeny. [

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Key concepts: Ameloblast, Transforming growth factor, Human tooth, Odontoblast, Immunohistochemistry, Dentin, Enamel paint, Cell biology