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2011•Medical Journal of West ChinaRequires access

Study of oxaliplatin combined with capecitabine for advanced gastric cancer

Shi Zeng-xiu

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Abstract

Objective We evaluated the antitumour activity and toxicities of oxaliplatin and capecitabine as therapy in geriatric patients with advanced gastric cancer(AGC).Methods Patients were treated with capecitabine 1000mg/m2 p.o.twice daily on days 1-14 and oxaliplatin 120mg/m2 i.v.on day 1 every 3 weeks until disease progression or unacceptable toxicities.Results 1 patient showed complete response and 12 showed partial response.The overall response rate 56.4%.Major toxicity was myelosuppression,enteric reaction and hand-foot syndrome.Conclusion Oxaliplatin and capecitabine combination chemotherapy is active and highly tolerable as a therapy for geriatric patients with AGC.

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What this paper is about

Objective We evaluated the antitumour activity and toxicities of oxaliplatin and capecitabine as therapy in geriatric patients with advanced gastric cancer(AGC).Methods Patients were treated with capecitabine 1000mg/m2 p.o.twice daily on days 1-14 and oxaliplatin 120mg/m2 i.v.on day 1 every 3 weeks until disease progression or unacceptable toxicities.Results 1 patient showed complete response and 12 showed partial response.The overall response rate 56.4%.Major toxicity was myelosuppression,enteric reaction and hand-foot syndrome.Conclusion Oxaliplatin and capecitabine combination chemotherapy is active and highly tolerable as a therapy for geriatric patients with AGC.

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Available abstract

Objective We evaluated the antitumour activity and toxicities of oxaliplatin and capecitabine as therapy in geriatric patients with advanced gastric cancer(AGC).Methods Patients were treated with capecitabine 1000mg/m2 p.o.twice daily on days 1-14 and oxaliplatin 120mg/m2 i.v.on day 1 every 3 weeks until disease progression or unacceptable toxicities.Results 1 patient showed complete response and 12 showed partial response.The overall response rate 56.4%.Major toxicity was myelosuppression,enteric reaction and hand-foot syndrome.Conclusion Oxaliplatin and capecitabine combination chemotherapy is active and highly tolerable as a therapy for geriatric patients with AGC.

Key concepts: Capecitabine, Oxaliplatin, Medicine, Internal medicine, Oncology, Gastroenterology, Chemotherapy, Toxicity

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