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2011•Chinese Journal of Practical StomatologyRequires access

Aetiology of oral submucous fibrosis

Yin Xiao-mi

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Abstract

Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. OSF is popular in India、Pakistan and many southeast-Asian countries,and Hunan and Taiwan province. The aetiology of OSF is obscure, areca nut chewing is the main aetiological factor for OSF. A clear dose-dependent relationship was observed for both frequency and duration of areca nut chewing in the development of OSF. All patients were chewers. areca nut chewing has strong association with the risk of OSF, oral leukoplakia (OL),and oral cancer (OC). Various factors, such as genetic predisposition,immunity,collagen-related genes, nurture deficiency,have been implicated in the development of OSF.

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What this paper is about

Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. OSF is popular in India、Pakistan and many southeast-Asian countries,and Hunan and Taiwan province. The aetiology of OSF is obscure, areca nut chewing is the main aetiological factor for OSF. A clear dose-dependent relationship was observed for both frequency and duration of areca nut chewing in the development of OSF. All patients were chewers. areca nut chewing has strong association with the risk of OSF, oral leukoplakia (OL),and oral cancer (OC). Various factors, such as genetic predisposition,immunity,collagen-related genes, nurture deficiency,have been implicated in the development of OSF.

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Available abstract

Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. OSF is popular in India、Pakistan and many southeast-Asian countries,and Hunan and Taiwan province. The aetiology of OSF is obscure, areca nut chewing is the main aetiological factor for OSF. A clear dose-dependent relationship was observed for both frequency and duration of areca nut chewing in the development of OSF. All patients were chewers. areca nut chewing has strong association with the risk of OSF, oral leukoplakia (OL),and oral cancer (OC). Various factors, such as genetic predisposition,immunity,collagen-related genes, nurture deficiency,have been implicated in the development of OSF.

Key concepts: Areca, Oral submucous fibrosis, Etiology, Medicine, Betel, Dermatology, Leukoplakia, Precancerous condition

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