Synergistical Suppressive Effect of Cadmium Chloride and Cisplatin on the Proliferation of Human Hepatoma Cell Line

BACKGROUND AND AIM:To investigate the synergistical suppressive effect of cadmium chloride and cisplation on the proliferation of human hepatoma cell line SMMC-7721.MATERIALS AND METHODS:Cytotoxicity of the drugs was measured by MTT assay.The coefficient of drug interaction(CDI) was used to analyze the synergistical suppressive effect of drug combination.RESULTS:0.56、1.12、2.25 μg/ml cadmium chloride and 0.25、0.5、1.0 μg/ml cisplatins had inhibitory effects on the proliferation of SMMC-7721.The inhibition in cells treated with both agents was significant increased with treatment time.CONCLUSION:The combination of cadmium chloride and cisplatin could inhibit the proliferation of human hepatoma cell line SMMC-7721.