Depression and Associated Factors in Pakinson's Disease

Objective To determine the frequency of depression in patients with Parkinson's disease(PD) and its associated factors.Methods The patients with PD were screened using Self-Rating Scale for Depression(SDS),and then divided into a depression group and a non-depression group by Hamilton Depression Rating Scale(HAMD).Using logistic regression,we analyzed the association of depression with onset age,demographic characteristics,family care status,the Hoehn and Yahr stage(HY),unified Parkinson's disease rating scale(UPDRS part Ⅱ) and Webster.Results There was significant difference in presence of carer,Webster score,HY,and UPDRS part Ⅱ between the two groups.The most important predictive factors for depression were presence of carer and UPDRS part Ⅱ.Conclusion Our results suggest that depression occurs frequently in patients with Parkinson's disease which was caused by several factors,and effective therapeutic intervention is required in treatment of Parkinson's disease.