Change and its clinical significance of pre-and post-treatment platelet parameters in thrombocytopenia

Objective To investigate the change and its clinical significance of pre-and post-treatment platelet parameters in thrombocytopenia to provide the guidance of clinical treatment.Methods A total of 102 patients with thrombocytopenia were studied,including 47 cases of idiopathic thrombocytopenia purpura(ITP),26 cases of aplastic anemia(AA) and 29 cases of acute leukemia(AL).The platelet total (PLT),plateletocrit (PCT),mean platelet volume(MPV),platelet distribution width (PDW) and platelet-large cell ratio(P-LCR) were detected before and after treatment by Sysmex XS-1000i automated blood cell analyzer.The detection results before and after treatment were compared and statistically analyzed with healthy controls.Results PLT and PCT before treatment in ITP group were significantly lower than that of healthy controls,while MPV,PDW and P-LCR were significantly higher compared with the control.In particular,PLT,PCT and MPV in AA and AL groups were significantly lower compared with the control group(P0.05).Additionally,PDW was significantly raised in AA group(P0.05).There was no significant difference in PLT,PCT values among ITP,AA and AL,but MPV,PDW and P-LCR in AA and AL groups were lower than those in ITP group.Furthermore,PLT and PCT were elevated in remission or clinical improvement of ITP,AA and AL.Meanwhile,MPV,PDW and P-LCR were markedly decreased in remission or clinical improvement of ITP.However,MPV and P-LCR were obviously elevated in remission of AA and AL.Conclusion The platelet parameters could provide the important clinical information about differential diagnosis and prognosis of thrombocytopenia.