The study of therapeutic effect of recombinant humen growth hormone in children with turner syndrome.

Objective To assese the efficacy of recombinant human growth hormone in promoting the growth in children with Turner syndrome.Methods 60 children with Turner syndrome were treated with subcutaneous injection of rhGH(0.15～0.18IU/(kg·d)daily before sleep for 3～18months.Results The growth velocity of these children increased from(2.33±0.71)cm to(8.51±1.31)cm after 3 months treatment,to(8.37±0.88) cm after 6 months treatment,to(7.56±1.35) cm after 12 months treatment.and to(7.18±1.89) cm after 24 months treatment.There were significant diference in the growth velocity before and after treatment(P0.05).There were no change in the mean body weight and BA during the whole course of rhGH therapy.During the course of rhGH therapy,no remarkable adverse effect was found,except that fewer patients suffered fromlocal reactions in injection sites and slight increasement of the erum ALT levels.Conclusion rhGH appears to be an effective and safe drug for promoting the growth in children with Turner syndrome.