2004•Guangzhou Zhongyiyao Daxue xuebaoRequires access
Effect of Weiyanxiao Granule on Experimental Gastric Ulcer
Qun Du
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Abstract
To observe the effect of Weiyanxiao Granule (WG) in counteracting experimental gastric ulcer,acute lesion of gastric mucosa and to investigate its anti-inflammation and analgesic actions.Acute gastric ulcer models induced by stress or indomethacin, chronic gastric ulcer models induced by acetic acid and models with acute lesion of gastric mucosa induced by hydrochloride-ethanol or 0.2 mol·L -1 sodium hydroxide were used to observe the effect of WG in counteracting experimental gastric ulcer and acute lesion of gastric mucosa. Anti-inflammation action of WG was observed on mouse models with auricular swelling induced by dimethylbenzene, rat models with pedal swelling induced by white egg and rat models with granuloma induced by embedding tampon. Hot plate method and body-torsion test were used to observe the analgesic action of WG. As compared with the control group, WG 12.3?g·kg -1 and 24.6?g·kg -1 could decrease the ulcer index in rats with acute gastric ulcer (P0.05 or P0.01),reduce the ulcer area in rats with chronic gastric ulcer (P0.01) and gastric lesion index in rats with acute lesion of gastric mucosa(P0.01). WG 24.6?g·kg -1 and 49.2?g·kg -1 could increase the pain threshold and reduce torsion times in mice and relieve dimethylbenzene-induced auricular swelling (P0.01). WG 12.3?g·kg -1 and 24.6?g·kg -1 could also relieve pedal swelling induced by white egg and decrease the weight of granuloma in rat models with granuloma induced by embedding tampon.[Conclusion]WG exerts a certain effect in counteracting experimental gastric ulcer, acute lesion of gastric mucosa and has anti-inflammation and analgesic actions.