Influence of target-controlled infusion of propofol on minimum alveolar concentration of sevoflurane

Objective To compare the influence of target-controlled infusion of different doses of propofol on the min-imum alveolar concentration (MAC) of sevoflurane. Methods 85 patients who received selective laparoscopic surgery in the gynecological department of our hospital were selected and randomly divided into the experimental group a,b,c,d and e from October 2010 to October 2012.The propofol plasma concentrations of the 5 groups were 1.0 μg/ml,1.5 μg/ml, 2.0 μg/ml,2.5 μg/ml respectively and simple inhalation of sevoflurane group e,it included 17 patients in each group. The influence of different propofol plasma concentrations on sevoflurane MAC and their interralation were studied and their rational compatibility regimen was explored. Results In terms of the MAC values of sevoflurane at T1-T4 , the sevoflurane MAC values of group e were significantly lower in the five groups ( P0.01). Compared to the other groups, group d had smaller dosage and frequency of vasoactive drugs and atropine use.The decrease of sevoflurane MAC values was in linear relationship with the increase of propofol plasma concentrations. Conclusion The propofol plasma concentration under target-controlled infusion of propofol has a reverse relationship with the sevoflurane MAC value-which is conducive to the clinical detection and diagnosis.Different concentrations of propofol have different influence on minimum alveolar concentrations (MAC)of sevoflurane.As the plasma concentration increases,the MAC of sevoflurane decreases.