Infection factors and distribution of human papilloma virus in married women of childbearing age in Dongguan area

Objective To explore the related factors and its subtype distribution characteristics of human papilloma virus(HPV) infection in married women of childbearing age in Dongguan area.Methods 4 332 married women of childbearing age were surveyed by confidentiality-style questionnaire.PCR-reverse dot blot hybridization method was adopted to detect 19 kinds of cervical HPV virus subtype,including HPV 16,HPV 18,HPV 31,HPV 33,HPV 35,HPV 39,HPV 45,HPV 51,HPV 52,HPV 53,HPV 56,HPV 58,HPV 59,HPV 66,HPV 68,HPV CP8304,HPV 6,HPV 11,HPV 43,at the same time liquid-based thin-layer cytology check was adopted.Results Among 4 332 married women of childbearing age,subtype HPV infection was detected in 398 cases,the total infection rate was 9.19%,high-risk infection rate was 7.55%.The high-risk subtypes standing in the front fifth place were HPV 16(2.216%),HPV 58(1.293%),HPV 52(0.877%),HPV 53(0.646%),HPV 33(0.600%).Single infections were in 340 cases(85.43%),double infections were in 49 cases(9.88%),three overlapping infections were in 5 cases(1.01%),and four overlapping infection were in 4 cases(0.815%),the differences among the groups were statistically significant(P 0.05).Conclusion HPV infection associated with age,occupation,frequency of sexual life,education level,early sexual life and pregnancy number.The HPV infection of women with low educational level is higher,it is necessary to strengthen the health knowledge propaganda in low educational level women,in order to prevent HPV infection and the incidence of cervical cancer.