2009•Journal of Taishan Medical CollegeRequires access

The research of the effect of curcumin on dopaminergic neurons in mouse model of parkinson's disease

Lingzhong Xu

Abstract

Objective:To investigate the protective effect of Curcumin on doparminergic neurons.Methods: C57BL6 mice were randomly divided into three groups: control group(DMSO,ip),MPTP group(15 mg/kg,ip) and Curcumin-pretreatment(10 mg/kg,ip) group.The changes of tyrosine hydroxylase(TH) and dopamine transport(DAT) gene expression in substantia nigra(SN) were detected by using reverse transcription-polymerase chain reaction(RT-PCR).The contents of DA and its metabolites dihydroxy-phenylacetic acid(DOPAC) were determined by high performance liquid chromatography-electrical chemical detection(HPLC-ECD).Results: Curcumin pretreatment could prevent the MPTP-induced decrease of TH and DAT gene ex-pression(P0.01).MPTP significantly decreased the levels of dopamine(DA) and its metabolites dihydroxy-phenylacetic acid(DOPAC) in the striatum,which could be restored by Curcumin pretreatment P0.01).Conclusion: Curcumin has neuroprotective effects on dopaminergic neurons against MPTP-induced mouse model of PD.

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Key concepts: MPTP, Curcumin, Dopaminergic, Substantia nigra, Tyrosine hydroxylase, Dopamine, Chemistry, Pharmacology