Epidemiological survey of prevalence of fatty liver and its risk factors in adult population of Chongming district,Shanghai

Objective To investigate the prevalence and risk factors of fatty liver among adult residents in Chongming District,Shanghai.Methods A cross-sectional survey with multiple stage stratified cluster and random sampling was performed.All residents aged from 40 to 70 were invited to participate the survey.Questionnaire,physical examination,serum lipid-profile,75 g oral glucose tolerance test and ultrasonography of liver were undertaken.Analysis of data was performed through SPSS 13.0 for windows statistical package.Results A total of 3 017 residents participated the survey,which was 80.15/10 000 of the residents.Of the 3 017 residents surveyed,882 were males and 2 135 were females.The mean age of the participants was(55.6±8.0) years and ranged from 40-70 years.Fatty liver was detected by ultrasound examination in 1 262 participants(41.83%).The age and gender adjusted prevalence of fatty liver was 21.25%.The standardized prevalence of fatty liver in males(24.53%) was similar to that in females(20.40%)(P0.05).The prevalence of non-alcoholic fatty liver was 88.75%(1 120/1 262) in fatty liver.Mean age,fasting plasma glucose(FPG),2 h plasma glucose(2hPG),systolic blood pressure(SBP),diastolic blood pressure(DBP),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),and alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyltransferase(GGT) in fatty liver group was significantly higher than that in non-fatty liver group(all P0.000 1);high density lipoprotein cholesterol(HDL-C) level was lower in fatty liver group than in non-fatty liver group(P0.000 1).Logistic regression analysis demonstrated that the prevalence of fatty liver was positively correlated with age,postprandial glucose level,TG,LDL-C,SBP,ALT,GGT.Conclusions There was a high prevalence of fatty liver among adult residents in Chongming district,Shanghai,and non-alcoholic fatty liver was the major type.Aging,diabetes mellitus,hypertension and dyslipidemia were the risk factors of fatty liver.