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2010•Practical Journal of Clinical MedicineRequires access

Tamsulosin in the treatment of urolithiasis

Xiang Yi

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Abstract

α1 adrenoreceptor blocker(α1-AB) has been regularly applied for benign prostate hyperplasia for years.As α1 adrenoreceptors have different distribution in human ureter confirmed by RT-PCR,α1-AB has begun to be used in the treatment of urolithiasis because of its spasmolysis.Compared with quinazolines,tamsulosin,with less efficacy on α1-B receptor and less impact on cardiovascular system,is a high selective blocker targeted on interrupting α1-A and D adrenoreceptors which are predominant in human ureter.This paper has summarized recent clinical achievement and to provide reference for clinicians.

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What this paper is about

α1 adrenoreceptor blocker(α1-AB) has been regularly applied for benign prostate hyperplasia for years.As α1 adrenoreceptors have different distribution in human ureter confirmed by RT-PCR,α1-AB has begun to be used in the treatment of urolithiasis because of its spasmolysis.Compared with quinazolines,tamsulosin,with less efficacy on α1-B receptor and less impact on cardiovascular system,is a high selective blocker targeted on interrupting α1-A and D adrenoreceptors which are predominant in human ureter.This paper has summarized recent clinical achievement and to provide reference for clinicians.

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Available abstract

α1 adrenoreceptor blocker(α1-AB) has been regularly applied for benign prostate hyperplasia for years.As α1 adrenoreceptors have different distribution in human ureter confirmed by RT-PCR,α1-AB has begun to be used in the treatment of urolithiasis because of its spasmolysis.Compared with quinazolines,tamsulosin,with less efficacy on α1-B receptor and less impact on cardiovascular system,is a high selective blocker targeted on interrupting α1-A and D adrenoreceptors which are predominant in human ureter.This paper has summarized recent clinical achievement and to provide reference for clinicians.

Key concepts: Tamsulosin, Medicine, Urology, Ureter, Hyperplasia, Prostate, Internal medicine, Cancer

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