2006•Zhongguo xin yao zazhiRequires access

Application of chiral stationary phases of chromatography on resolution of chiral drugs

Yin Dali

Abstract

Chiral stationary phases (CSPs) have the potential for the analytical and preparative resolution of chiral drugs by chromatographies.This paper highlights five categories of chromatographic techniques with CSPs,four mobile-phase regimens in HPLC-Supercritical Fluid Chromatography (SFC) CSPs and six categories of HPLC-SFC CSPs.The strategies for the selection of chromatographic columns with CSPs and the transit of preparative processes from analytical processes by CSPs in the resolution of chiral drugs are also addressed.

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Key concepts: Supercritical fluid chromatography, Chiral stationary phase, Chromatography, Resolution (logic), High-performance liquid chromatography, Chemistry, Chiral column chromatography, Enantiomer