Clinical Observances on Radiotherapy with Concurrent Chemotherapy in Non-operable Advanced Non-small Cell Lung Cancer

Objective To evaluate the effect and complication of radiotherapy combined with concurrent chemotherapy for NSCLC patients.Methods Sixty eight patients with non operational NSCLC of grade Ⅲ were randomly divided into two groups:radiotherapy with concurrent chemotherapy (Group A) and radiotherapy alone (Group B).The involved field radiation was adopted in radiotherapy,2 0 Gy/d,5 d/w,and the total tumor dose was 66-68 Gy/6 6-7 0 weeks.The chemotherapy adopted EP region for squamous cell carcinoma and MVP region for adenocarcinoma.The frist chemotherapy cycle was undergone with radiotherapy concurrently.The second cycle was undergone at the four weeks after radiotherapy began,and another two cycles were used after radiotherapy completed.Results Total effective rates were 76 5% in Group A and 52 9% in Group B,the difference was statistically significant(χ 2=4 121, P =0 044).The 1 ,2 and 3 year survial rates were 70 6%,50 1%,35 3% in Groud A and 52 9%,26 5%,14 7% in Group B, P 0 05.Conclusion Combined chemotherapy with cisplatin in major with concurrent radiotherapy can improve tumor control rate of NSCLC,reduce the rate of matastasis,and so can improve long survival rate.