EXPERIMENTAL STUDY OF THE EXPRESSION OF COX-2 ON CORNEAL NEOVASCULARIZATION AND SELECTIVE COX-2 INHIBITORS DEPRESSANT EFFECT

Objective:To detect the expression of COX-2 and VEGF in the corneal neovascularization(CNV) and evaluate the depressant effect of COX-2 selective inhibitor for cautery-induced rat CNV.Methods:In Wistar rats,a model of experimental CNV was induced by alkaline burn.The CNV was studied by slit-lamp and histopathology.The expression of COX-2 and VEGF was detected by immunohistochemistry.Results:The inflammatory cell infiltration was observed markedly in alkaline burn group and the new vessels of cornea is abundant.Above-mentioned changes of the treated group was lessened obviously than alkaline burn.The expression of COX-2 and VEGF was increased markedly in the corneal alkaline burn and was suppressed significantly in treated group(P0.01).The changes of COX-2 and VEGF were parallel with the corneal pathohistological process.The expression of COX-2 was markedly related to VEGF(P0.05).Conclusion:The COX-2 and VEGF were participated in inflammation-associated CNV.COX-2 selective inhibitor inhibits the cautery-induced CNV,and the results indicated the COX-2 selective inhibitor could inhibit and delay the genesis and development of CNV.