Correlation between level of serum high mobility group box-1 and acute coronary syndrome in patients with type 2 diabetes mellitus

Objective To investigate the correlation between serum high mobility group box-1(HMGB1) level and acute coronary syndrome(ACS) in patients with type 2 diabetes mellitus(DM). Methods The study consisted of 234 noncoronary artery disease patients(control group) and 218 patients with ACS(ACS group), which included 95 patients with unstable angina pectoris(UAP) and 123 patients with acute myocardial infarction(AMI). Two hundred and thirty-four healthy subjects served as controls. Serum levels of HMGB1, high sensitivity C-reactive protein(hsCRP) and tumor necrosis factor(TNF)-α were measured using commercially available enzyme-linked immunosorbent assay(ELISA) kits.Results Serum HMGB1 level was significantly elevated in AMI and UAP groups as compared with controls [(12.70±6.72) μg/L,(7.68±3.63) μg/L vs.(3.83±1.72) μg/L, P0.01)]; levels of hsCRP[(3.30±2.97) mg/L,(1.46±1.37) mg/L vs.(0.83±0.69) mg/L,P0.05] and TNF-α [(71.04±38.34) ng/L,(52.69±24.76) ng/L vs.(43.27±20.56) ng/L, P0.01] were also significantly increased in AMI and UAP groups when compared with those of controls. Moreover, serum HMGB1 levels in patients of each group with DM were higher than the counterparts without DM(all P0.05). HMGB1 level was closely correlated with hsCRP, TNF-α and fasting plasma glucose(FG) levels. Conclusions Serum HMGB1 Ievel was increased in patients with ACS, and HMGB1 level was higher in patients with DM than those without DM. These results indicated that HMGB1 might be involved in the development and progress of ACS, and the impact was more prominent in the presence of DM.