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2011•Journal of Clinical Pulmonary MedicineRequires access

The clinic efficacy of tiotropium in patients with mild to moderate COPD

Xun Fang

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Abstract

Objective Evaluation of tiotropium clinic efficacy in patients with mild chronic obstructive pulmonary disease(COPD).Methods In this 12 week,randomised,double-blind,placebo-controlled study of tiotropium 18 mcg once daily versus placebo in the patients with mild to moderate COPD,their respiratory function were assessed on Days 1,15 and 85(baseline: pre-dose Day 1).Results The mean FEV1(% predicted) of all was 73.4±12.5.The baseline in area under the curve from pre-dose to 2 hours post-dose(AUC0-2h) FEV1 in Tiotropium group significantly improved(P0.0001).The rates of adverse event were similar between two groups.Conclusion Tiotropium can significantly improve the lung function in patients with mild to moderate COPD.

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What this paper is about

Objective Evaluation of tiotropium clinic efficacy in patients with mild chronic obstructive pulmonary disease(COPD).Methods In this 12 week,randomised,double-blind,placebo-controlled study of tiotropium 18 mcg once daily versus placebo in the patients with mild to moderate COPD,their respiratory function were assessed on Days 1,15 and 85(baseline: pre-dose Day 1).Results The mean FEV1(% predicted) of all was 73.4±12.5.The baseline in area under the curve from pre-dose to 2 hours post-dose(AUC0-2h) FEV1 in Tiotropium group significantly improved(P0.0001).The rates of adverse event were similar between two groups.Conclusion Tiotropium can significantly improve the lung function in patients with mild to moderate COPD.

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Available abstract

Objective Evaluation of tiotropium clinic efficacy in patients with mild chronic obstructive pulmonary disease(COPD).Methods In this 12 week,randomised,double-blind,placebo-controlled study of tiotropium 18 mcg once daily versus placebo in the patients with mild to moderate COPD,their respiratory function were assessed on Days 1,15 and 85(baseline: pre-dose Day 1).Results The mean FEV1(% predicted) of all was 73.4±12.5.The baseline in area under the curve from pre-dose to 2 hours post-dose(AUC0-2h) FEV1 in Tiotropium group significantly improved(P0.0001).The rates of adverse event were similar between two groups.Conclusion Tiotropium can significantly improve the lung function in patients with mild to moderate COPD.

Key concepts: Medicine, COPD, Tiotropium bromide, Placebo, Adverse effect, Lung function, Internal medicine, Pulmonary disease

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