Analysis of the balance regulation mechanism of Montelukast on Th1/Th2 cell function of peripheral blood in asthmatic children

Objective:To investigate the clinical efficacy of Montelukast and to explore its balance regulation mechanism of Montelukast on Th1/Th2 cell function of peripheral blood in asthmatic children.Methods:78 cases of children with bronchial asthma were randomly divided into treatment group and control group in our hospital from December 2008 to December 2010,39 cases in each group.Oxygen uptake,relieving asthma,anti-inflammatory,anti-infection and other basic treatment were given to both groups,thus Montelukast tablets 4 mg/d,orally,once a day for three months were given to the treatment group on the basis of basic treatment.IL-4,IFN-γ levels and IFN-γ/IL-4 ratio changes before and after 3 months treatment were compared,the total efficiency of the two groups were compared,and the disappearance time of cough,asthma and wheezing sound were observed in the two groups.Results:The IFN-γ level of treatment group [(41.45±6.61) ng/L] was significantly higher than that of control group [(46.57±7.42) ng/L](t=2.42,P0.05);the IL-4 level of treatment group [(41.45±6.61) ng/L] was significantly lower than that of control group [(46.57±7.42)ng/L](t=2.68,P0.05);the IFN-γ/IL-4 ratio of treatment group(1.83±0.42) was significantly increased than that of control group(1.56±0.37)(t=2.13,P0.05).The total effective rate of treatment group was 92.31%,and the total efficiency of control group was 74.36%,the difference was statistically significant(χ2=12.537,P0.01).The disappearance time of cough,asthma and wheezing sound of treatment group [(2.68±1.15),(5.19±1.25),(4.17±1.75) d)] were significantly shorter than those of control group [(4.43±1.27),(6.70±1.63),(6.25±1.64) d](t=2.35,2.14,2.41,P0.01).Conclusion:Montelukast in the treatment of patients with bronchial asthma is effective and safe,which can significantly improve the clinical symptoms and signs.The mechanism may relate to the balance regulation of Th1/Th2 cell function in children with asthma.