Effects of noninvasive mechanical ventilation on C-reactive protein changes in patients with acute left ventricular failure

AIM:To observe the therapeutic effect of noninvasive mechanical ventilation on patients with acute left ventricular failure and the changes of C-reactive protein(CRP).METHODS:A total of 53 patients with acute left heart failure were randomly divided into two groups:conventional group of 27 patients treated with high-flow oxygen and routine drug therapy and noninvasive ventilation group of 26 cases treated with bi-level noninvasive positive pressure ventilation via face mask and routine drug therapy.Clinical efficacy and CRP levels in the two groups were assessed.RESULTS:The effective rates in noninvasive ventilation group and conventional group were,respectively,96%and 70%,with statistically significant differences(P 0.05).Twenty-four hours after treatment,CRP levels were significantly lower than those before treatment(P0.01) and the difference between the two groups was statistically significant(P0.01).After treatment,systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR) and respiratory rate(RR) were significantly lower than those before treatment(P 0.01),whereas PaO_2 and SpO_2 increased(P 0.01).One hour after treatment,a statistically significant difference was observed in SBP,DBP,HR,RR,PaO_2 and SpO_2 between conventional group and noninvasive ventilation group(P 0.01 or 0.05).Twenty-four hours after treatment,a statistically significant difference was seen in PaO_2 and SpO_2 between groups(P0.01).CONCLUSION:Noninvasive mechanical ventilation can improve the treatment efficacy in patients with acute left ventricular failure and reduce the level of CRP.