Antihypertensive Efficacy of Compound Candesartan Cilexetil/HTCZ Assessed by 24-hour Ambulatory Blood Pressure Monitoring in Patients With Essential Hypertension

Objectives:To compare the antihypertensive efficacies of candesartan cilexetil 16 mg/HTCZ12.5 mg with candesartan cilex- etil 16mg after 8 weeks treatment by 24-hour ambulatory blood pressure monitoring(ABPM). Methods:A randomized,double-blind,parallel-group study of Can/HTCZ(group 1)versus Can(group 2)was conducted in 55 patients with mild-to-moderate essential hypertension whose target sitting diastolic BP was not achieved(SeDBP 90 mmHg)after 4 weeks treatment with 8 mg candesartan cilexetil once-daily were undergone ABPM.Changes of daytime and night-time diastolic(DBP)and systolic blood pressures(SBP)by A BPM were compared.Tough peak ratio(TPR)and smooth- ness index(SI)were calculated for each group. Results:The mean BP(SBP/DBP)at 24h,daytime and night-time by ABPM in group 1(n = 28)decreased by 15.86± 8.24/8.75±6.23 mmHg,17.04±9.60/10.00±6.87 mmHg and 14.61±9.92/7.64±7.57 mmHg;and in group 2(n =27) decreased by 5.15±7.67/4.44±4.59 mmHg,6.70±7.12/5.26±4.49 mmHg and 4.11±10.78/3.52±6.47 mmHg respec- tively.The T/P ratio of SBP and DBP were 99.36%(19.16/19.28 mmHg)and 87.36%(10.14/11.61 mmHg)in group 1; and 4.42%(7.30/ 13.41 mmHg)and 64.86%(6.43/9.91 mmHg)in group 2 respectively. Conclusion:Compared with Can 16 mg,the compound Can 16 mg and HCTZ 12.5 mg presented the better effect to the pa- tients with essential hypertension,and the compound product could reduce the blood pressure in a greater degree with longer time. The everage ambulatory blood pressure reducing model was like day timewhole daynight time,SBPDBP.The compound product may decease the blood pressure in a smoother way.