Influence of carbon dioxide pneumoperitoneum during laparoscopic surgery on hemodynamic changes and coagulation-fibrinolytic parameters

Objective: To investigate the influence of laparoscopic and open operation on hemodynamics,peritoneal coagulationfibrinolysis system in the treatment of benign ovarian cyst and uterine fibroids. Methods: Forty-nine patients were selected in the laparoscopic group,and 43 patients were selected in the laparotomy therapy group,D-dimer( D-D) level,blood gas analysis,tissue type plasminogen activator( t-PA),urinary type plasminogen activator( u-PA) were detected before and after treatment respectively. Results:Inner-group comparisons showed that,in the two groups,D-D level after treatment increased,the differences were statistically significant( P 0. 05). Inter-group comparisons showed that,D-D level of the two groups after treatment had no significant difference,positive rate of t-PA and u-PA in the two groups had no significant difference. Before and after pneumoperitoneum,PCO2 and p H were significantly different( P 0. 01),and change of PCO2 was highly correlated with duration of ventilation. After treatment,p H of the laparotomy therapy group was significantly higher than that of the laparoscopic group( P 0. 05),PO2 of the two groups did not significantly changed.Conclusions: Laparoscopic and open operations have influence on blood gas,but have no significant effect on coagulation-fibrinolysis system.