Expressions and Significance of EGFR,C-erbB-2,VEGF and COX-2 in Human Gastric Cancer Tissues

Objective To detect the expressions of epidermal growth factor receptor(EGFR),epidermal growth factor receptor-2(C-erbB-2),vascular endothelial growth factor(VEGF) and cyclooxgenase-2(COX-2) in gastric cancer tissues,and to analyze the relationship among them and the clinicopathologic factors of gastric cancer.Methods The SP immunohistochemical stain was used to detect EGFR,C-erbB-2,VEGF and COX-2 protein expressions in sample of 68 gastric cancer tissues.And their corresponding clinical data were analyzed retrospectively.Results The expression rates of EGFR,C-erbB-2,VEGF and COX-2 protein in gastric cancer tissue were 38.2%(26/68),42.6%(29/68),52.9%(36/68) and 60.3%(41/68) corresponding.An obvious increasing tendency as the differentiation of the cancer degraded,invasion depth deepened,lymphatic metastasis occurred and TNM stage upgraded was showed by the positive expression rates of them(P0.05,P0.01);but there was no correlation with the patient's sex,age,tumour site and size(P0.05).There was a stable positive correlation among EGFR,C-erbB-2,VEGF and COX-2 expressions in gastric cancer tissue,respectively(P0.05).Conclusion EGFR,C-erbB-2,VEGF and COX-2 expressions participate in the development,invasion and metastasis process of gastric cancer.Joint detection of them can be looked as an important symbol for judging the prognosis of gastric cancer and screening the high-risk metastasis patients,and guiding the molecular targeting therapy of gastric cancer.