2012•Chemical Research and ApplicationRequires access

Synthesis and study on antitumor activities of indolinedione Schiff bases and their complexes

Niangen Chen

Abstract

Several schiff base ligands and their transition metal Cu(Ⅱ)、Zn(Ⅱ)、Mn(Ⅱ)、Co(Ⅱ)、Ni(Ⅱ)complexes were prepared and characterized by UV-Vis,IR and 1H NMR.Antitumor activities of the complexes in vitro were studied by the method of MTT.Structures studied by UV-Vis,IR and 1H NMR were basically in accordance with our prediction.Test results of L1·Zn complex's antitumor activity in vitro had been acquired.Complex L1·Zn showed a weak inhibition effect on tumor cells SPCA-1,Tb,MGC and K562,potentially because of indoledione single-Schiff base ligand and metal Zn.The complexes of L2 had antitumor activity.Among the five complexes,the Cu(Ⅱ)complex had the novel highest antitumor activity.

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Key concepts: Schiff base, Chemistry, In vitro, Ligand (biochemistry), Proton NMR, Metal, Stereochemistry, Nuclear chemistry